For years, for my son's acoustic duo act, he used a Behringher 22 track mixer into a Fender Passport 250 portable PA. It worked OK; he used the mixer because it sounded better than the Passport's built in mixer. Anyway, he used 3 ft instrument cables to connect the mixer to the Passport with no noticeable problems.
Now, he has upgraded to one of those Bose PA's. He has the Model 1 version, with the bigger base and a 4 channel mixer in the base. He was playing a show with his full electric band at a bar over the weekend, and used the Bose as the PA (just for vocals). It has plenty of power for that (the bar they were playing at likes them to keep the volume down). Anyway, they went into the mixer and then into one channel of the Bose. When using an instrument cable for that, there was a tremendously loud hissing sound from the Bose; it was unuseable. Substituting a speaker wire for the instrument cable between the mixer and Bose greatly reduced the hiss, and using patch cables instead pretty much eliminated it.
Also, the Bose expects unbalanced inputs. On our mixer, the main outs are balanced, but the sub-group outs are unbalanced. So, running from the main outs into the PA with patch cables doesn't eliminate the hiss, but running from a subgroup output into the PA with a patch cable does.
So... problem solved. But I am wondering: Why? Why did instrument cables work in the past and not now? Is there a specific type of patch cable that's recommended for this job? What is the difference between speaker cabkles, patch cables, and instrument cables? As you can tell, I know next to nothing about PA's, but I'm trying to learn.