I noticed recently after having favored my Tele and Les Paul, I'll go back to the Strat, and it feels like home. I don't know what it is; my Tele has basically the same neck, but it's not as comfortable to play. In my case, it has nothing to do with body shape.
And I was talking to a buddy, who like me started off with a Strat. He's got a small but great collection of guitars, but he said the same thing about his Strat. His 335 is incredible: I've played it, and the sound is so good, and it feels good to play, but he's more comfortable on the Strat.
And it is just a comfortable guitar to play-weight, neck. My Ric 330 rivals it--the neck is so wonderful to play. It feels like I've been playing it for years.