I love my 2008 AmStd Strat with 62/whatever vintage pickups. I dreamt of having a Strat that I can milk Clapton and Gilmour tones from.
But sometimes, I wish I had a second Strat, with a more powerful pickup set. I'd probably get some SD Hot Rails. I'm not thinking of buying anything in the near future. When I do buy a second Strat, it'll probably be an AmPro. I like the hardware and tone. The stock pickups are good, and I might stick with them. If not, I'll be as happy as a hog in mud with a change to the Duncans.