One of my teachers was a blues guy who went on to jazz, so he spent a lot of time with me on this kind of thing. His advice? Before venturing too far afield of the minor/major pentatonics, consider two things:
1) Who are you playing with? How comfortable are they with stepping outside the old tried and true formula? If they're not too comfortable with it, don't go there, or it stops the flow of musical communication. He likened this to reading comprehension -- if th reader reads at an 8th grade level, don't write at a PhD. level, or you won't understand each other very well.
2) Who are you playing for? The same concepts apply here, but with perhaps even more importance. I went to hear Allan Holdsworth, Jeff Berlin, and Chad Wackerman one evening, and they were all over the map, melodically, harmonically, and rhythmically. After about 3 tunes, my brain hurt -- and I love "outside" stuff.
Sometimes, sticking to pentatonics, and just tossing a very light sprinkling of other stuff in is perfect. Robben Ford does this quite well, IMO.
Just my $.02